Michael Hoffmann
Erforschung der Entstehung einer Amyotrophen Lateral Sklerose
Dr. rer. nat.
Biologe
Publikationen
Hinweis:
Über die PubMed ID (PMID) können die entsprechenden Veröffentlichungen leicht gefunden werden unter:
Projekt |01
Epitheliale Polarität und Entwicklung
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Hoffmann M, Segbert C, Helbig G, Bossinger O.
Dev Biol 2010. Intestinal tube formation in Caenorhabditis elegans requires vang-1 and egl-15 signaling. PMID: 20004187
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Honnen SJ, Büchter C, Schröder V, Hoffmann M, Kohara Y, Kampkötter A, Bossinger O.
PLoS One 2012. C. elegans VANG-1 modulates life span via insulin/IGF-1-like signaling. PMID: 22359667
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Bossinger O and Hoffmann M, Intechopen 2012
Development and Cell Polarity of the C. elegans Intestine. ISBN 978-954-51-0544-2
Honnen S, Bossinger O and Hoffmann M, AJST 2014. Planar Cell Polarity Proteins VANG-1 and DSH-2 contribute to JNK-1 activation in C. elegans embryogenesis. Der Link zur Veröffentlichung
Bossinger O, Wiesenfahrt T and Hoffmann M. Cell Polarity 2 - Role in Development and Disease 2015. Establishment and Maintenance of Cell Polarity in the C. elegans intestine. ISBN 978-3-319-144465-8..
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Waaijers S, Munoz J, Berends C, Ramalho JJ, Goerdayal SS, Low T, Zoumaro-Djayoon AD, Hoffmann M, Koorman T, Tas RP, Harterink M, Seelk S, Kerver J, Hoogenraad CC, Bossinger O, Tursun B, van den Heuvel S, Heck AJR, Boxem M. BMC Biology 2016 - A tissue-specific protein purification approach in C. elegans identifies novel interaction partners of DLG-1. PMID: 27506200.
Projekt |02
Mitochondrienfunktion
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Hoffmann M, Bellance N, Rossignol R, Koopman WJ, Willems PH, Mayatepek E, Bossinger O, Distelmaier F. PLoS One 2009. C. elegans ATAD-3 is essential for mitochondrial activity an development. PMID: 19888333
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Hoffmann M, Honnen S, Mayatepek E, Wätjen W, Koopman WJ, Bossinger O, Distelmaier F.
Exp Geront 2012. MICS-1 interacts with mitochondrial ATAD-3 and modulates lifespan in C. elegans. PMID: 22245785

van den Ecker D, van den Brand MA, Ariaans G, Hoffmann M, Bossinger O, Mayatepek E, Nijtmans LG, Distelmaier F.
Identification and functional analysis of mitochondrial complex I assembly factor homologues in C. elegaMitochondrion 2012. ns. PMID: 22387847
van den Ecker D*, Hoffmann M*, Müting G, Maglioni S, Herebian D, Mayatepek E, Ventura N, Distelmaier F. BBRC 2015. C. elegans ATAD-3 modulates mitochondrial iron and heme homeostasis. PMID: 26427876
*equally contributing authors
Projekt |03
Neurodegenerative Erkrankungen
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Hoffmann M. Med Hypotheses 2013. Linking respiratory chain uncoupling to amyotrophic lateral sclerosis implies potential treatment with herbal extracts containing genipin. PMID: 23265356
Hoffmann M. Front. Neurol. 2013. Enhanced uncoupling of the mitochondrial respiratory chain as a potential source for amyotrophic lateral sclerosis. doi: 10.3389/fneur.2013.00086
Hoffmann M. 2014. AASCIT communications, Vol.1 (2), July 2014. Vicious Circle of Metaboreflex Dysregulation in Amyotrophic Lateral Sclerosis.
Der Link zur Veröffentlichung.
Hoffmann M. 2014. Über die mögliche Entstehung der Amyotrophen Lateral Sklerose. CreateSpace Independent Publishing Platform. ISBN-10: 1503379469. Der Link zur Veröffentlichung.
Hoffmann M. 2015. The Origin of Amyotrophic Lateral Sclerosis. CreateSpace Independent Publishing Platform. ISBN-10: 1519549660. Der Link zur Veröffentlichung.
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Hoffmann M. 2018. ALS und Lebenserwartung. CreateSpace Independent Publishing Platform. ISBN-10: 1986834174. Der Link zur Veröffentlichung.